STIM1 as a Potential Biomarker for Increased Risk of Community-Acquired Pneumonia in Asthmatic Children: A Prospective Cohort Study

Authors

  • Beibei Yang Department of Pediatrics, The First Affiliated Hospital of An Hui Medical University, Hefei, China https://orcid.org/0009-0004-4037-6149
  • Yu-huan Deng Department of Pediatrics, The First Affiliated Hospital of An Hui Medical University, Hefei, China
  • Sheng-gang Ding Department of Pediatrics, The First Affiliated Hospital of An Hui Medical University, Hefei, China; Beijing Children’s Hospital, Capital Medical University, China National Clinical Research Center of Respiratory Diseases, Beijing, China

DOI:

https://doi.org/10.71321/jqsynp20

Abstract

Aim: To study the correlation between serum STIM1 level and high susceptibility to pneumonia in children with asthma.

Methods: A total of 116 children hospitalized at our facility as the study subjects, which were categorized into three groups: pneumonia complicated with asthma group, pneumonia group, asthma group. 30 healthy children were selected as a blank group. The concentrations of serum STIM1 were measured and compared across all groups.

Results: The study measured serum STIM1 concentrations (pg/ml) in the pneumonia complicated with asthma group , pneumonia group , asthma group and blank group, which were (398.6 ± 17.54), (349.9 ± 17.84), (360.2 ± 35.88), and (418.1 ± 14.40), respectively. The data showed that there were statistical differences in serum STIM1 concentration in different conditions (P < 0.05).

Conclusions: STIM1 is involved in the occurrence and development of bronchial asthma and CAP, and related to CAP with high susceptibility to asthma.

References

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Type

Research Article

Published

2025-05-15

Data Availability Statement

All data needed to evaluate the conclusions in the paper are present in the paper or the Supplementary Materials. Additional data related to this paper may be requested from the authors.

Issue

Vol. 1 (2025)

Section

Clinical and Translation Research

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How to Cite

Yang, B., Deng, Y.- huan, & Ding, S.- gang. (2025). STIM1 as a Potential Biomarker for Increased Risk of Community-Acquired Pneumonia in Asthmatic Children: A Prospective Cohort Study. Cell Conflux, 1, e234. https://doi.org/10.71321/jqsynp20