Use of Autologous hematopoietic stem cell transplantation for a patient with primary nasal NK/T-cell lymphoma combined with hemophagocytic syndrome

Mingquan Xing; Chunbo  Feng; Weixia Wu; Yanrong Zhang; Siqi Zhang; Xiaoxing Sun; Hongfeng Ge

doi:10.71321/sx17sm66

Authors

Mingquan Xing Department of Hematology, Bozhou People's Hospital,BoZhou
Chunbo Feng Otolaryngology department,Bozhou People's Hospital,BoZhou, Anhui, People’s Republic of China
Weixia Wu Image Center, Bozhou People's Hospital,BoZhou, Anhui, People’s Republic of China
Yanrong Zhang Department of Hematology, Bozhou People's Hospital,BoZhou, Anhui, People’s Republic of China
Siqi Zhang Department of Hematology, Bozhou People's Hospital,BoZhou, Anhui, People’s Republic of China
Xiaoxing Sun Department of Hematology, Bozhou People's Hospital,BoZhou, Anhui, People’s Republic of China
Hongfeng Ge Department of Hematology, Bozhou People's Hospital,BoZhou, Anhui, People’s Republic of China

DOI:

https://doi.org/10.71321/sx17sm66

Keywords:

Extranodal NK/T-cell lymphoma, hemophagocytic syndrome, autologous hematopoietic stem cell transplantation

Abstract

Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a type of primary nasal peripheral T-cell lymphoma, which is a rare type of non-Hodgkin's lymphoma, especially with hemophagocytic syndrome (HPS), and can easily lead to clinical misdiagnosis. The disease is dangerous, it progresses rapidly, and the treatment is ineffective. This article reports a case of ENKTCL-NT with HPS, which involves the primary nasal cavity invading the oral cavity. Patients attain improved remission outcomes with autologous hematopoietic stem cell transplantation (ASCT) in combination with chemotherapy. This paper reviews current domestic and international research and summarizes diagnostic and therapeutic approaches to enhance clinicians' comprehension of the disease.