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Author Guidelines

Advancing scientific knowledge through rigorous peer review and open access publishing

Our Mission

Life Conflux is committed to fostering scientific excellence by providing a platform for researchers to share groundbreaking discoveries, innovative methodologies, and comprehensive analyses. We bridge the gap between theoretical knowledge and practical applications, ensuring that scientific progress benefits society through open, accessible, and rigorously peer-reviewed publications.

Editorial Standards & Commitment

Research Integrity

We maintain the highest standards of scientific integrity, ensuring all published research adheres to ethical guidelines and contributes meaningfully to the scientific community.

Open Access Excellence

Our open access model ensures that groundbreaking research reaches the global scientific community without barriers, accelerating knowledge dissemination and collaboration.

Rigorous Peer Review

Our single-blind peer review process, conducted by leading experts in their respective fields, ensures the quality and validity of all published research.

Terms of Submission

By submitting a manuscript to Life Conflux, authors acknowledge and agree to the following terms:

  • Originality Commitment: The submitted manuscript represents original work that has not been published elsewhere and is not under consideration by any other journal or publisher.
  • Author Agreement: All listed authors have read, approved, and agree to the submission of the manuscript and accept responsibility for its content.
  • Open Access License: Upon publication, the content will be freely available under an open access license for non-commercial use, promoting global knowledge sharing.
  • Copyright Compliance: The manuscript content does not infringe upon any third-party copyrights, patents, or other intellectual property rights.
  • Data Transparency: Authors commit to making research data available in accordance with open science principles and journal policies.

Peer Review Process

Single-Blind Review System

Life Conflux employs a rigorous single-blind peer review process designed to maintain objectivity and ensure the highest quality of published research. This system protects reviewer anonymity while maintaining transparency in the evaluation process.

Review Timeline & Process:

  1. Initial Editorial Screening: 7-10 business days for editorial assessment and reviewer assignment
  2. Peer Review: 3-4 weeks for comprehensive expert evaluation by 2-3 independent reviewers
  3. Editorial Decision: 1-2 weeks for final editorial decision and author notification
  4. Publication Process: 2-3 weeks from acceptance to online publication

Article Types & Specifications

Life Conflux welcomes diverse scholarly contributions that advance scientific knowledge and promote interdisciplinary collaboration. Each article type serves specific purposes within the scientific communication ecosystem, from original research and comprehensive reviews to expert opinions and editorial communications.

Research Article

Description: Comprehensive reports of original research findings, experimental studies, or theoretical analyses that make significant contributions to scientific knowledge and understanding

Word Limit: 3,000-6,000 words, 4-6 figures, unlimited supplements

Abstract: Required (Structured)

Special Requirements: Data & Code Availability, IRB Statement, Ethics Approval

Short Communication

Description: Concise reports of preliminary findings, novel observations, or significant developments that warrant rapid dissemination to the scientific community

Word Limit: 1,500-3,000 words, 1-3 figures

Abstract: Required (Structured)

Special Requirements: Fast-track review available

Review Article

Description: Comprehensive synthesis of current knowledge, systematic analysis of literature, and critical evaluation of developments in specific research areas

Word Limit: 3,000-12,000 words, 2-6 figures/tables, extensive references

Abstract: Required (Unstructured)

Special Requirements: Minimum 50 references, expert author credentials

Perspective

Description: Expert opinions on emerging trends, future directions, or innovative approaches to current challenges in scientific research and practice

Word Limit: 3,000-5,000 words, 2-4 figures

Abstract: Required (Unstructured)

Special Requirements: Future research directions, policy implications

Method

Description: Procedural method in the design and implementation of an experiment or study. Detailed methodological innovations and technical procedures

Word Limit: 3,000-12,000 words, unlimited figures

Abstract: Required (Unstructured)

Special Requirements: Troubleshooting section, detailed procedures

Protocol

Description: Procedural protocol in the design and implementation of an experiment or study. Step-by-step protocols that can be followed and reproduced

Word Limit: 3,000-12,000 words, unlimited figures

Abstract: Required (Unstructured)

Special Requirements: Troubleshooting section, validation data

Opinion

Description: Personal opinions on a topic that enhances the understanding of the subject, providing expert perspectives on current issues or controversies

Word Limit: No specific limit

Abstract: No

Special Requirements: Expert author credentials

Editorial

Description: To convey an opinion, or overview of an issue, by the Editor or someone invited by the editor. Addresses journal policies, field developments, or editorial perspectives

Word Limit: No specific limit

Abstract: No

Special Requirements: Editorial invitation required

Commentary

Description: Expert opinion from one or more people (who may agree or disagree) on a published work, current understanding/status of an area, or how practice should be undertaken. Generally with references

Word Limit: No specific limit

Abstract: No

Special Requirements: Reference to original work, expert credentials

Correspondence

Description: A letter, or response to a letter, sent to the journal to raise a point of interest, discuss a difference of opinion or encourage participation

Word Limit: No specific limit

Abstract: No

Special Requirements: Brief and focused

Analysis

Description: Overview of developments in fields or the current lines of thought. Synthesizes multiple sources of information and has long list of references. Emphasis is more factual and less on opinion

Word Limit: 3,000-12,000 words

Abstract: Required (Unstructured)

Special Requirements: Data and Code Availability

Submission Requirements & Materials

Required Submission Materials

All manuscripts must include the following materials in the specified formats. Failure to include any required item may result in immediate return without review.

  1. Manuscript: Required, must be uploaded in Word format. Should not contain any main figures or main tables. For revised manuscripts, must provide both clean and marked versions showing all changes.
  2. Title Page: Required, must be uploaded in Word format. Must include detailed author information, complete institutional affiliations, and corresponding author email address.
  3. Graphical Abstract: Required, must be in JPG format. Should provide a clear visual summary of the main findings or methodology. High resolution (minimum 300 DPI) required.
  4. Highlights: Required, must be uploaded in Word format. Should contain 3-5 bullet points (maximum 85 characters each) summarizing the key findings and significance of the work.
  5. Figures: Required, all figures must be submitted in JPG format. Figures must be grouped into a single compressed ZIP file for upload.
  6. Figure Legends: Required, must be uploaded in Word format (.doc or .docx). Should clearly describe each figure and include any relevant details such as abbreviations, symbols, or experimental conditions.
  7. Declarations File: Required, must be uploaded in Word format. Must include all sections detailed below, even if some sections are marked as "Not Applicable."

Optional Submission Materials

These materials enhance the submission and may be required depending on the article type and content.

  1. Cover Letter: Optional, if applicable, must be uploaded in Word format. Should explain the significance and novelty of the research and address any potential concerns.
  2. Tables: Optional, if applicable, must be uploaded as a compressed package in Word format. All tables must be three-line tables with titles above and notes below.
  3. Supplementary Figures: Optional, if applicable, must be in JPG format and uploaded as a compressed package. Should support but not duplicate main figures.
  4. Supplementary Tables: Optional, if applicable, must be uploaded as a compressed package in Word format. Should follow the same three-line table format as main tables.
  5. Raw Data: Optional, if applicable, must be uploaded as a compressed package. Original datasets that support the findings and enable reproducibility.

Declarations File - Detailed Requirements

The declarations file must include all of the following sections in the exact order specified. Each section is mandatory and must be present even if marked as "Not Applicable."

  1. Abbreviations: If there are abbreviated terms in the article, provide corresponding abbreviations and full names in alphabetical order. If none: Write "Not Applicable."
  2. Author Contributions: Clearly describe each author's specific contributions to the research and manuscript preparation. Use standard CRediT taxonomy when possible.
  3. Acknowledgements: If there are acknowledgments, briefly describe the acknowledgment information including technical assistance, editorial help, or other support. If none: Write "Not Applicable."
  4. Funding Information: If there is funding, briefly describe the funding information including grant numbers, funding agencies, and sponsor organizations. If none: Write "Not Applicable."
  5. Ethics Approval and Consent to Participate: If there are ethics considerations, briefly describe the ethics information including IRB approval numbers, consent procedures, and compliance statements. If none: Write "Not Applicable."
  6. Competing Interests: If there are competing interests, briefly describe the competing interests information including financial relationships, personal relationships, or professional affiliations that could be perceived as influencing the research. If none: Write exactly: "The authors declare that they have no existing or potential commercial or financial relationships that could create a conflict of interest at the time of conducting this study."
  7. Data Availability: If no data availability statement is needed: Write "Not Applicable." If a data availability statement is needed: Write exactly: "All data needed to evaluate the conclusions in the paper are present in the paper or the Supplementary Materials. Additional data related to this paper may be requested from the authors."

Manuscript Structure & Format

Research Article Format (IMRaD Structure)

Title & Abstract

Compelling title (≤200 characters), structured abstract (200-250 words) with Background, Methods, Results, Conclusions

Introduction

Research context, literature review, knowledge gaps, objectives, and hypotheses clearly stated

Methods

Detailed methodology, materials, procedures, statistical analyses, and ethical considerations

Results

Key findings, statistical analyses, data presentation with figures and tables

Discussion

Interpretation of results, comparison with literature, implications, and limitations

Conclusion

Synthesis of key findings, broader implications, and future research directions

Structured Abstract Template

Background: State the research problem, significance, and objectives. Explain why this study was necessary and what gap it addresses in current knowledge.

Methods: Describe study design, participants/samples, key methodological approaches, data collection, and analytical approaches used.

Results: Present main findings with specific data, statistical significance, and key quantitative/qualitative outcomes.

Conclusions: Summarize main conclusions, practical implications, and contributions to the field. Suggest future research directions.

Keywords: 5-7 relevant keywords separated by semicolons

Technical Formatting Requirements

Typography & Layout

  • Font: Arial, 11pt, justified alignment
  • Line Spacing: Double-spaced throughout
  • Margins: 1-inch (2.54 cm) on all sides
  • Page Numbers: Bottom center, starting from title page
  • Headings: Bold, no numbering, hierarchical structure

Scientific Notation

  • Numbers: Comma separation for >9,999 (e.g., 10,000)
  • Multiplication: Use × symbol (not X or *)
  • Statistics: p < 0.05 (spaces around operators)
  • Gene Names: Standard formatting (no italics)
  • Serial Lists: Oxford comma required (A, B, and C)

Important Formatting Notes: Manuscripts must be submitted as separate Word documents without embedded figures or tables. All formatting should follow standard academic conventions with clear section breaks and consistent styling throughout.

References & Citation Style

Vancouver Citation System

Life Conflux follows the Vancouver referencing system with sequential numeric citations. Each reference receives a unique Arabic number assigned in order of first appearance, maintained throughout the manuscript when cited again.

Citation Examples:

Journal Articles (≤6 authors):

Zhou, G., Li, . A., & Wang, R. (2025). The role of IL-17 family in the process of pulmonary fibrosis. Life Conflux, 1(3), e217. https://doi.org/10.71321/tg620c27

Journal Articles (>6 authors):

Huang HJ, Liu C, Sun XW, Wei RQ, Liu LW, Chen HY, et al. The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses. (2024). iMeta. 3(5):e242. https://doi.org/10.1002/imt2.242

Books:

Thomson AK, editor. Molecular mechanisms in cardiovascular disease: clinical applications. 3rd ed. New York: Academic Press; 2023.

Online Resources:

World Health Organization. Global health observatory data repository [Internet]. Geneva: WHO; 2024 [cited 2024 Oct 15]. Available from: https://www.who.int/data/gho

In-Text Citations:

  • Superscript format: text¹ or text¹⁻³
  • Bracket format: text [1] or text [1-3]
  • Multiple citations: [1,3,5-7]

Reference Management:

  • EndNote style file available
  • DOI required when available
  • Complete page ranges

Figures, Tables & Visual Elements

Figure Requirements

  • Format: JPEG (photos) or TIFF (graphics)
  • Resolution: Minimum 300 DPI
  • Size: Single or double column width
  • Labels: Clear, readable fonts (Arial 8-12pt)
  • Color: High contrast, colorblind-friendly
  • Legends: Comprehensive, standalone descriptions

Table Specifications

  • Format: Three-line table structure
  • Title: Above table, descriptive and concise
  • Headers: Clear column headings with units
  • Data: Consistent decimal places and formatting
  • Notes: Below table for explanations
  • Statistics: Significance indicators clearly defined

Best Practices for Visual Elements: Ensure all figures and tables are self-explanatory and can be understood independently of the main text. Use consistent styling, clear labeling, and provide detailed legends that explain all symbols, abbreviations, and statistical measures used.

Data Availability & Research Ethics

Data Transparency

Life Conflux promotes open science principles and requires transparent reporting of research data and methodologies.

  • Data availability statement required
  • Code and analysis scripts when applicable
  • Repository links for shared datasets
  • Restrictions and access conditions clearly stated

Research Ethics

All research involving human participants, animals, or sensitive data must comply with ethical standards and institutional guidelines.

  • IRB/Ethics committee approval
  • Informed consent documentation
  • Animal welfare compliance (if applicable)
  • Conflict of interest disclosure

Submission Process & Editorial Workflow

Editorial Workflow Steps

  1. Submission: Upload manuscript and required materials through online portal
  2. Editorial Review: Initial assessment for scope, quality, and reviewer assignment
  3. Peer Review: Expert evaluation by independent reviewers in relevant fields
  4. Publication: Final editorial decision, production, and online publication

Submission Checklist

Before Submission:

  • Manuscript follows journal guidelines
  • All required files prepared
  • Ethics approval obtained (if applicable)
  • All authors approve submission

Quality Assurance:

  • Data and methodology clearly described
  • References properly formatted
  • Figures and tables high quality
  • Statistical analyses appropriate

Editorial Contact & Support

Editorial Office

For submission inquiries and editorial matters

Email: editorial@lifeconflux.com

Technical Support

For submission system and technical issues

Email: support@lifeconflux.com

Fast Track Review

For urgent research communications

Email: fasttrack@lifeconflux.com

Submission Preparation Checklist

All submissions must meet the following requirements.

Biomedical Data Science and Analytics

Bioinformatics research in cellular biology integrates computational and statistical techniques to analyze and interpret complex biological data at the cellular level. This interdisciplinary field bridges computer science with molecular and cell biology, providing tools for understanding cellular processes and functions.

Researchers apply bioinformatics methods to study gene expression, protein-protein interactions, metabolic pathways, and signaling networks. Advanced algorithms and machine learning models are used to predict cellular behavior, identify disease biomarkers, and understand genetic variations that contribute to phenotypic diversity.

Advances in high-throughput technologies such as next-generation sequencing (NGS) have generated vast amounts of genomic, transcriptomic, proteomic, and metabolomic data. Bioinformatics plays a critical role in managing and analyzing this 'big data', enabling researchers to uncover novel insights into cellular mechanisms and develop personalized medicine approaches.

Cellular biology benefits greatly from bioinformatics through the construction of detailed cellular maps and models. By integrating multi-omics data, researchers can simulate cellular responses to environmental changes, drugs, or genetic modifications. This leads to better strategies for therapeutic interventions and drug discovery.

In conclusion, the Bioinformatics Research in Cellular Biology section of our journal aims to present leading-edge research findings and promote collaboration among computational biologists, cell biologists, and clinicians. We focus on the development and application of computational tools that enhance our understanding of cellular systems and contribute to biomedical advances.

Clinical Decision Support and AI in Medicine

Cancer research in cellular biology is a vibrant and expanding field that delves into the fundamental mechanisms of cancer at the cellular level. By understanding how cancer cells form, grow, and spread, researchers are developing new therapies and treatment strategies to combat this devastating disease.

The focus of cellular biology in cancer research is on the intricate processes that govern cell division, DNA repair, cell signaling, and cell death. Aberrations in these processes can lead to the uncontrolled growth and spread of cancer cells. By studying these mechanisms, scientists are uncovering new targets for therapeutic intervention.

Advanced technologies, such as CRISPR/Cas9 gene editing, single-cell sequencing, and high-throughput screening, are revolutionizing cancer research in cellular biology. These tools enable researchers to manipulate genes, analyze individual cells, and identify potential drug candidates with unprecedented precision.

Collaboration among cellular biologists, oncologists, geneticists, and bioinformaticians is essential for advancing cancer research in cellular biology. This multidisciplinary approach fosters innovation and accelerates the translation of basic research findings into clinical applications. For example, by combining cellular biology insights with clinical data, researchers are developing personalized medicine approaches that tailor treatments to individual patients.

In conclusion, the Cancer Research in Cellular Biology section of our journal aims to showcase cutting-edge research and facilitate academic exchange in this exciting field. Here, we document the latest discoveries and advancements in understanding the cellular mechanisms of cancer. We believe that through continued support and engagement with this research community, we can make significant contributions to improving cancer outcomes and patient care.

Digital Health and Public Health Informatics

Public health research in biological sciences integrates epidemiology, genetics, microbiology, and environmental health to understand the factors that influence population health and disease prevention. This interdisciplinary field seeks to uncover the biological mechanisms underlying health disparities and develop strategies for improving public health outcomes.

Researchers in this area investigate a broad spectrum of topics, from infectious diseases and chronic conditions to the impact of environmental exposures on human health. Studies often involve large-scale data analysis, biomonitoring, and molecular epidemiology to identify risk factors and protective elements within populations. Public health researchers also explore how genetic variability influences susceptibility to disease and response to treatments.

Advances in public health research have led to significant improvements in vaccination programs, infection control measures, and health policy development. Innovations in diagnostics, such as rapid testing technologies and personalized medicine approaches, have enhanced our ability to detect and manage diseases early. Moreover, the integration of genomics into public health practices is opening new avenues for targeted interventions and preventive strategies.

Biological sciences play an essential role in guiding the formulation of public health policies and guidelines. By understanding the molecular and cellular bases of diseases, researchers can provide evidence-based recommendations for interventions that reduce morbidity and mortality. This knowledge is critical for addressing global health challenges, including emerging infectious diseases, antimicrobial resistance, and non-communicable diseases.

In conclusion, the Public Health Research in Biological Sciences section of our journal aims to highlight pioneering research findings and promote collaboration among epidemiologists, biologists, clinicians, and policymakers. We focus on studies that enhance our understanding of the biological determinants of health and apply this knowledge to improve public health interventions and policies.

Methods, Algorithms and Software

This section focuses on the core principles of cellular biology and their relevance to disease mechanisms. It covers the regulation of cellular pathways, interactions between various biomolecules, and the identification of molecular markers that underpin pathological processes. By integrating these fundamental insights, researchers can develop more accurate diagnostic assays and discover promising therapeutic targets.

Recent advances in high-throughput technologies—such as single-cell sequencing, multi-omics analyses, and CRISPR-based gene editing—have revolutionized our ability to detect and characterize disease at the cellular level. These innovations enable precision diagnosis, improve patient stratification, and pave the way for targeted therapies. Coupling these cutting-edge techniques with robust data analytics further refines our understanding of cellular mechanisms and accelerates clinical translation.

Looking ahead, continued exploration of cell-to-cell variability and integrative analysis of molecular data are poised to transform diagnostics and therapeutics. Efforts to personalize treatments based on a patient’s unique cellular and genetic profile will expand, driven by advances in predictive modeling and artificial intelligence. Additionally, increased collaboration between clinicians, researchers, and industry partners will foster next-generation diagnostic platforms and novel therapeutics.

Potential Submission Topics
  1. Novel biomarkers and molecular signatures for early disease detection
  2. Single-cell and multi-omics approaches in diagnostics and treatment planning
  3. CRISPR and gene-editing techniques for therapeutic intervention
  4. AI-driven analytics and predictive modeling for personalized medicine
  5. Translational research linking cellular biology findings to clinical applications
  6. Innovative assays, lab-on-a-chip platforms, and point-of-care diagnostic tools

Medical Informatics Cases, Reviews and Applications

Cardiovascular research in cellular biology is a pivotal area that delves into the fundamental mechanisms underlying heart and vascular function at the cellular level. This field plays a crucial role in understanding the cellular and molecular basis of cardiovascular diseases, paving the way for novel therapeutic strategies and diagnostic approaches.

Research in cellular biology has uncovered intricate signaling pathways, genetic mutations, and cellular processes that contribute to the development and progression of cardiovascular diseases. By elucidating these mechanisms, scientists can identify new targets for drug development and design more effective treatment strategies tailored to individual patients.

Advances in cellular technologies, such as CRISPR gene editing, stem cell therapy, and high-throughput screening, are revolutionizing cardiovascular research. These tools enable researchers to manipulate genes, study cellular differentiation, and identify potential therapeutic compounds more efficiently. This, in turn, accelerates the translation of basic research findings into clinical applications.

The intersection of cellular biology with other disciplines, such as bioinformatics, biophysics, and systems biology, is fostering a deeper understanding of cardiovascular physiology and pathology. Collaborative efforts among researchers from diverse fields are driving innovation and leading to the discovery of new insights into the complex mechanisms governing heart and vascular health.

In conclusion, the Cardiovascular Research in Cellular Biology section of our journal aims to be a leading platform for presenting cutting-edge research and facilitating academic exchange in this vital area. We strive to highlight the relentless pursuit of knowledge by scientists and celebrate the milestones they achieve in unraveling the cellular and molecular basis of cardiovascular diseases. Through continuous support and engagement with this field, we aspire to make significant contributions to improving human health.

Medical Knowledge Intelligence

Allergy and respiratory research in cellular biology focuses on understanding the cellular and molecular mechanisms that underlie allergic responses and respiratory diseases. This interdisciplinary field integrates immunology, cell biology, and pulmonary physiology to explore the complex interactions between environmental factors, immune cells, and lung tissue.

Researchers in this area investigate a wide range of conditions, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and various forms of allergies such as hay fever and food allergies. They study how allergens trigger immune responses, the role of inflammatory mediators, and the involvement of specific cell types like mast cells, eosinophils, and T-helper cells in the pathogenesis of these diseases.

Advances in allergy and respiratory research have led to significant improvements in diagnostics, treatments, and prevention strategies. Innovations include the development of biologics targeting specific cytokines or antibodies involved in allergic reactions, personalized medicine approaches based on genetic profiling, and advanced imaging techniques for monitoring lung function and structure. Moreover, there is growing interest in exploring the gut-lung axis and the impact of microbiota on respiratory health.

Cellular biology plays a critical role in guiding the discovery of new therapeutic targets and interventions. By investigating the signaling pathways and cellular processes involved in inflammation and immune regulation, researchers can identify potential drugs or therapies that could modulate these responses. Understanding these mechanisms also aids in predicting patient responses to different treatments and developing tailored therapies.

In conclusion, the Allergy and Respiratory Research in Cellular Biology section of our journal aims to highlight cutting-edge research findings and promote collaboration among immunologists, pulmonologists, biologists, and clinicians. We emphasize studies that advance our understanding of the cellular and molecular bases of allergic and respiratory diseases and apply this knowledge to develop innovative diagnostics and therapies.

Precision Medicine Informatics

This section focuses on cutting-edge immunological studies with a strong emphasis on cellular biology. It explores the intricate cellular and molecular mechanisms that drive immune responses in health and disease. Topics include, but are not limited to, the role of immune cells in various pathological conditions, signaling pathways in immune regulation, cell-cell interactions within the immune system, and the development of novel immunotherapeutic strategies.

Submissions may cover a wide array of topics such as:

  • Advances in the understanding of T-cell, B-cell, and macrophage biology
  • The role of immune cells in tissue homeostasis, repair, and inflammation
  • Cellular dynamics in transplant immunology, graft rejection and immune tolerance
  • The interplay between immune cells and the tumor microenvironment
  • The application of single-cell multi-omics technologies in unraveling immune heterogeneity

We encourage studies employing innovative methodologies, including single-cell analysis, spatiotemporal omics and advanced imaging, to deepen the understanding of immune cell biology. The section aims to provide a platform for high-quality, original research and comprehensive reviews that contribute to advancing the field of cellular immunology.

Submissions should highlight the relevance of their findings to the broader immunology and cellular biology communities, offering translational potential for therapeutic applications.

Copyright Notice

Submission of a manuscript to the Life Conflux journal directly implies that all the authors have read and agreed to the journal's guidelines. The content present in the manuscript after publication will be freely available to all the potential readers over the Internet for non-commercial use.

The content provided by the authors in the manuscript should at no point of time breach the Copyrights or rights of a third party. The manuscript submitted should not be published or submitted for consideration in any other journal. Manuscripts with plagiarized content will not be considered for the peer-review process.

Privacy Statement

Effective Date: October 1, 2024

At Life Conflux Press, we are committed to protecting your privacy and ensuring the security of your personal information. This Privacy Policy outlines how we collect, use, store, and protect your data when you interact with our website, services, and products. By using our services, you agree to the terms outlined in this policy.

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If you have any questions or concerns about this Privacy Policy or our data practices, please contact us at:

  • Email: privacy@lifeconfluxpress.com
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