A Unique Case of Migraine Without Aura Triggered by Palpation ofV2-innervated Chronic Facial Folliculitis

Dan Xiao; Yu Wang

doi:10.71321/jynd6h07

Authors

Dan Xiao Department of Neurology, Epilepsy and Headache Group, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China
Yu Wang Department of Neurology, Epilepsy and Headache Group, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China

DOI:

https://doi.org/10.71321/jynd6h07

Keywords:

Facial folliculitis, Migraine without aura, Trigeminal nerve, Neurogenic immunomodulation, Peripheral trigger, CGRP

Abstract

Accumulating research suggests that peripheral pathological changes participate in the pathogenesis of migraine, and supporting evidence has been reported in many clinical cases. However, few cases have directly demonstrated the bidirectional interaction between migraine and peripheral pathological lesions. Here, we present a case of severe migraine without aura (MwoA) whose attacks were elicited by palpation of chronic folliculitis lesions around the unilateral nasal ala.This unique case reveals a distinct peripheral-central interaction in migraine, which may be mediated by neurogenic immunomodulation of the trigeminal system.

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